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Epigenetics of the yeast galactose genetic switch

DSpace at IIT Bombay

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Title Epigenetics of the yeast galactose genetic switch
 
Creator BHAT, PJ
IYER, RS
 
Subject saccharomyces-cerevisiae
escherichia-coli
gal
memory
heterogeneity
induction
evolution
regulon
network
autoregulation
epigenetics
gal genes
stochasticity
transcriptional memory
 
Description The transcriptional activation of enzymes involved in galactose utilization (GAL genes) in Saccharomyces cerevisiae is regulated by a complex interplay between three regulatory proteins encoded by GAL4 (transcriptional activator), GAL3 (signal transducer) and GAL80 (repressor). The relative concentrations of the signal transducer and the repressor are maintained by autoregulation. Cells disabled for autoregulation exhibit phenotypes distinctly different from that of the wild type cells, enabling us to explore the biological significance of autoregulation. The redundancy in signal transduction due to the presence of GAL1 (alternate signal transducer) also makes it a suitable model to understand the phenomenon of epigenetics. In this article we review some of the recent attempts made to understand the importance of epigenetics in the establishment of cellular and transcriptional memory.
 
Publisher INDIAN ACAD SCIENCES
 
Date 2011-08-01T22:03:28Z
2011-12-26T12:53:31Z
2011-12-27T05:39:46Z
2011-08-01T22:03:28Z
2011-12-26T12:53:31Z
2011-12-27T05:39:46Z
2009
 
Type Article
 
Identifier JOURNAL OF BIOSCIENCES, 34(4), 513-522
0250-5991
http://dspace.library.iitb.ac.in/xmlui/handle/10054/8558
http://hdl.handle.net/10054/8558
 
Language en