Record Details

Silica-Coated Liposomes for Insulin Delivery

DSpace at IIT Bombay

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Field Value
 
Title Silica-Coated Liposomes for Insulin Delivery
 
Creator DWIVEDI, N
ARUNAGIRINATHAN, MA
SHARMA, S
BELLARE, J
 
Subject controlled drug-delivery
poorly soluble drugs
controlled-release
microporous silica
raman-spectroscopy
oral delivery
nanoparticles
vesicles
systems
spheres
 
Description Liposomes coated with silica were explored as protein delivery vehicles for their enhanced stability and improved encapsulation efficiency. Insulin was encapsulated within the fluidic phosphatidylcholine lipid vesicles by thin film hydration at pH 2.5, and layer of silica was formed above lipid bilayer by acid catalysis. The presence of silica coating and encapsulated insulin was identified using confocal and electron microscopy. The native state of insulin present in the formulation was evident from Confocal Micro-Raman spectroscopy. Silica coat enhances the stability of insulin-loaded delivery vehicles. In vivo study shows that these silica coated formulations were biologically active in reducing glucose levels.
 
Publisher HINDAWI PUBLISHING CORPORATION
 
Date 2011-07-31T07:22:24Z
2011-12-26T12:52:53Z
2011-12-27T05:39:50Z
2011-07-31T07:22:24Z
2011-12-26T12:52:53Z
2011-12-27T05:39:50Z
2010
 
Type Article
 
Identifier JOURNAL OF NANOMATERIALS, (), -
1687-4110
http://dx.doi.org/10.1155/2010/652048
http://dspace.library.iitb.ac.in/xmlui/handle/10054/8027
http://hdl.handle.net/10054/8027
 
Language en