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Transition metal saccharide chemistry and biology: Synthesis, characterization, electrochemistry and EPR studies of oxovanadium(IV) complexes of saccharides and their derivatives and in vitro interaction of some of these with ribonuclease and deoxyribonuclease

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Title Transition metal saccharide chemistry and biology: Synthesis, characterization, electrochemistry and EPR studies of oxovanadium(IV) complexes of saccharides and their derivatives and in vitro interaction of some of these with ribonuclease and deoxyribonuclease
 
Creator SREEDHARA, A
RAO, CP
RAO, BJ
 
Subject titanium-carbohydrate complexes
electron-spin-resonance
enantioselective syntheses
aqueous-solution
iron(iii) complexes
state-analog
blood-cells
vanadate
coordination
spectroscopy
transition metal saccharide chemistry
oxovanadium(iv)-saccharide complexes
in vitro rnase inhibition
transition-state analogues
hydrolytic stability
 
Description Low molecular weight, water-soluble saccharide complexes of oxovanadium(IV) have been synthesized and characterized by analytical, spectroscopic and electrochemical techniques. All the complexes were found to be mononuclear, possessing the VO2+ moiety, These are shown to be hydrolytically and oxidatively stable over a wide range of pH (1-12) and have been extensively characterized by absorption and EPR spectroscopy and by electrochemistry, Several correlations have been drawn from the data generated. Some of these complexes have been demonstrated to possess in vitro RNase inhibition activity with no effect on DNase. This suggests that these molecules closely mimic the substrate portion of the RNase-catalysed RNA hydrolysis and can act as transition-state analogues to RNase. (C) 1996 .
 
Publisher ELSEVIER SCIENCE BV
 
Date 2011-07-27T04:11:51Z
2011-12-26T12:53:32Z
2011-12-27T05:39:52Z
2011-07-27T04:11:51Z
2011-12-26T12:53:32Z
2011-12-27T05:39:52Z
1996
 
Type Article
 
Identifier CARBOHYDRATE RESEARCH, 289(), 39-53
0008-6215
http://dx.doi.org/10.1016/0008-6215(96)00100-0
http://dspace.library.iitb.ac.in/xmlui/handle/10054/7111
http://hdl.handle.net/10054/7111
 
Language en