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Synthesis and characterization of biocompatible hydroxyapatite coated ferrite

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Title Synthesis and characterization of biocompatible hydroxyapatite coated ferrite
 
Creator DEB, S
GIRI, J
DASGUPTA, S
DATTA, D
BAHADUR, D
 
Subject magnetic-properties
products
bioceramics
hyperthermia
ferrite
biocompatible coating
 
Description Ferrite particles coated with biocompatible phases can be. used for hyperthermia treatment. of cancer. We have synthesized substituted calcium hexaferrite, which is not stable on its own, but is stabilized with small substitution of La. Hexaferrite of chemical composition (CaO)(0.75)(La2O3)(0.20)(Fe2O3)(6). was prepared using citrate gel method. Hydroxyapatite was prepared by precipitating it from aqueous solution of Ca(NO3)(2) and (NH4)(2)HPO4 maintaining pH above 11. Four different methods were used for coating of hydroxyapatite on ferrite particles. SEM with EDX and X-ray diffraction analysis shows clear evidence of coating of hydroxyapatite on ferrite particles. These coated ferrite particles exhibited coercive field up to 2 kOe, which could be made useful for hysteresis heating in. hyperthermia. Studies by culturing BHK-21 cells and WBC over the samples show evidence of biocompatibility. SEM micrographs and cell counts give clear indication of cell growth on the surface of the sample. Finally coated ferrite particle was implanted in Kasaulli mouse to test its biocompatibility. The magnetic properties and biocompatibility studies show that these hydroxyapatite coated ferrites could be useful for hyperthermia.
 
Publisher INDIAN ACADEMY SCIENCES
 
Date 2011-08-02T08:14:42Z
2011-12-26T12:53:47Z
2011-12-27T05:40:48Z
2011-08-02T08:14:42Z
2011-12-26T12:53:47Z
2011-12-27T05:40:48Z
2003
 
Type Article
 
Identifier BULLETIN OF MATERIALS SCIENCE, 26(7), 655-660
0250-4707
http://dx.doi.org/10.1007/BF02706759
http://dspace.library.iitb.ac.in/xmlui/handle/10054/8722
http://hdl.handle.net/10054/8722
 
Language en