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Sonochemical stabilization of ultrafine colloidal biocompatible magnetite nanoparticles using amino acid, L-arginine, for possible bio applications

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Title Sonochemical stabilization of ultrafine colloidal biocompatible magnetite nanoparticles using amino acid, L-arginine, for possible bio applications
 
Creator THEERDHALA, S
BAHADUR, D
VITTA, S
PERKAS, N
ZHONG, ZY
GEDANKEN, A
 
Subject surface
iron
growth
sonochemistry
drug delivery
magnetite
amino acid
stable colloidal solution
 
Description Materials obtained by the synergistic combination of nanotechnology and biomedicine are an important source of drug delivery and other health care related applications The anchoring of amino acids onto the surface of nano-sized magnetite is one such example. Herein, we report on the binding of a semi-essential amino acid, L-arginine, onto the surface of nano magnetite, creating a stable aqueous suspension by an in situ one-step method using sonochemical synthesis An ex situ two-step process was also attempted, but was soon discarded owing to the relative short duration of the suspension attributed to increase in particle size and lower extent of binding The initial concentration of the amino acid was found to play an important role in controlling the particle size and also the binding motif Lower concentrations of arginine were found to favor the formation of elongated tubular structures, while at higher concentrations, the elongated structures were less prominent and arginine was found to be adsorbed onto the surface of the magnetite This surface-functionalized nanomagnetite with amino acids could become a promising vehicle for drug delivery. (C) 2009
 
Publisher ELSEVIER SCIENCE BV
 
Date 2011-07-26T18:24:13Z
2011-12-26T12:55:32Z
2011-12-27T05:41:03Z
2011-07-26T18:24:13Z
2011-12-26T12:55:32Z
2011-12-27T05:41:03Z
2010
 
Type Article
 
Identifier ULTRASONICS SONOCHEMISTRY, 17(4), 730-737
1350-4177
http://dx.doi.org/10.1016/j.ultsonch.2009.12.007
http://dspace.library.iitb.ac.in/xmlui/handle/10054/6989
http://hdl.handle.net/10054/6989
 
Language en