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Association of hemorheological parameters and risk of stroke in hypertensives of Indian origin

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Title Association of hemorheological parameters and risk of stroke in hypertensives of Indian origin
 
Creator BANERJEE, R
NAGESWARI, K
PUNIYANI, RR
 
Subject arterial-hypertension
blood viscosity
red cell rigidity
hypertension
stroke
 
Description The blood viscosity parameters of one hundred and fifty cases of WHO grade I and II hypertension of Indian origin, on treatment with calcium antagonists, were measured and a six-monthly follow up was conducted for a period of three years. The whole blood viscosity (WBV), plasma viscosity (PV), red cell rigidity (RG) and hematocrit (Hct) were monitored. Occurrence of stroke was considered as the outcome variable and it was observed that sixteen cases of stroke occurred during the follow up period (10.7% incidence). After excluding known risk factors of age, sex, addictions, blood pressure levels, cholesterol levels and underlying diseases, it was observed that an increased whole blood viscosity > 6 centiPoise was associated with an increased risk of stroke (Relative risk 2.9, 95% confidence interval 2.2 to 3.7). An increased red cell rigidity in a hypertensive patient was found to be an independent risk factor for stroke. Patients with red cell rigidity greater than 4 had 4 times (Relative risk 3.6, 95% confidence interval 3.2 to 4) higher risk of stroke as compared with patients with red cell rigidity levels less than 4. Treatment with drugs modifying the rheological profile and aiming at improving the red cell deformability should thus be considered in hypertensive patients in an attempt to prevent the occurrence of stroke.
 
Publisher MARCEL DEKKER INC
 
Date 2011-08-18T07:45:22Z
2011-12-26T12:55:38Z
2011-12-27T05:41:40Z
2011-08-18T07:45:22Z
2011-12-26T12:55:38Z
2011-12-27T05:41:40Z
2000
 
Type Article
 
Identifier CLINICAL AND EXPERIMENTAL HYPERTENSION, 22(7-8), 687-694
1064-1963
http://dx.doi.org/10.1081/CEH-100102000
http://dspace.library.iitb.ac.in/xmlui/handle/10054/9931
http://hdl.handle.net/10054/9931
 
Language en