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Effects of variation in intercellular electrical coupling on synaptic potentials in smooth muscle: A computational study

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Title Effects of variation in intercellular electrical coupling on synaptic potentials in smooth muscle: A computational study
 
Creator SOURAV, S
MANCHANDA, R
 
Subject pig vas-deferens
junction potentials
gap-junctions
vascular tissues
communication
heptanol
contractility
varicosities
modulation
channel
bidomain model
electrophysiology
smooth muscle
synaptic potentials
syncytium
 
Description We have computationally explored the effect of quantitative variations in the extent of cell-to-cell electrical coupling on the synaptic potentials generated in smooth muscle. Neuronally produced spontaneous excitatory junction potentials (SEJPs) generated in a cubical "bidomain" model of syncytial tissue were simulated computationally. It was found that SEJP properties vary conspicuously as the principal parameter of interest, the cell-to-cell coupling resistance, Ri, is altered. For example, on increasing Ri, SEJP peak amplitudes at node zero (the node of generation) increase dramatically, while amplitudes at nodes 1 and 2 (which are passively depolarized) become progressively lower fractions of the amplitude of the zeroeth-node SEJP. The time to peak of the SEJPs also increases concomitantly when R-i is elevated. These observations indicate the nature of variations in synaptic potentials that would be expected under conditions of altered intercellular electrical coupling in smooth muscle. We discuss their implications in relation to the physiology of syncytial tissue, and in the context of recent experimental observations made in the presence of a putative inhibitor of cell-to-cell electrical coupling, 1-heptanol.
 
Publisher MARCEL DEKKER INC
 
Date 2011-08-18T09:25:07Z
2011-12-26T12:55:40Z
2011-12-27T05:41:59Z
2011-08-18T09:25:07Z
2011-12-26T12:55:40Z
2011-12-27T05:41:59Z
2001
 
Type Article
 
Identifier ELECTRO- AND MAGNETOBIOLOGY, 20(2), 193-205
1061-9526
http://dx.doi.org/10.1081/JBC-100104143
http://dspace.library.iitb.ac.in/xmlui/handle/10054/9959
http://hdl.handle.net/10054/9959
 
Language en