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Study of tablet-coating parameters for a pan coater through video imaging and Monte Carlo simulation

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Title Study of tablet-coating parameters for a pan coater through video imaging and Monte Carlo simulation
 
Creator KANDELA, B
SHEOREY, U
BANERJEE, A
BELLARE, J
 
Subject pan coating
tablet movement
video imaging
monte carlo simulation
coating variability
 
Description The movement of tablets in a pan coater and the exposure of different surfaces of tablets for deposition of coatings by spray-coating have been studied by video imaging and Monte Carlo simulation techniques. A representative variety of tablets of different shapes and sizes were used at different pan loads and at various pan speeds. A single "tracer" tablet was used to track the motion of tablets and coating variables such as circulation time, surface time, projected surface area and surface velocity of a tablet were determined from the video imaging experiments. The coating uniformity is described in terms of the coating variation from tablet to tablet CV(tt) and a new parameter CV(st) the coating variation on a single tablet. The effect of shape of tablets on coating uniformity was analyzed by introducing a "sphericity" of tablet (phi(s)) into the CV models. The methodology, new models and the analysis developed here incorporating the additional parameters will help users to optimize the coating process in pan-coating operations. (C) 2010
 
Publisher ELSEVIER SCIENCE SA
 
Date 2011-07-28T21:07:32Z
2011-12-26T12:47:21Z
2011-12-27T05:42:04Z
2011-07-28T21:07:32Z
2011-12-26T12:47:21Z
2011-12-27T05:42:04Z
2010
 
Type Article
 
Identifier POWDER TECHNOLOGY, 204(1), 103-112
0032-5910
http://dx.doi.org/10.1016/j.powtec.2010.07.024
http://dspace.library.iitb.ac.in/xmlui/handle/10054/7498
http://hdl.handle.net/10054/7498
 
Language en