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STEREOSELECTIVE TOTAL SYNTHESIS OF (2R,2'S,3Z)-1-0-(2-METHOXYHEXADECENYL)GLYCEROL AND (2R,2'S)-1-(2'-METHOXYHEXADECYL)GLYCEROL-POTENTIAL ANTITUMOR COMPOUNDS FROM SHARK LIVER OIL

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Title STEREOSELECTIVE TOTAL SYNTHESIS OF (2R,2'S,3Z)-1-0-(2-METHOXYHEXADECENYL)GLYCEROL AND (2R,2'S)-1-(2'-METHOXYHEXADECYL)GLYCEROL-POTENTIAL ANTITUMOR COMPOUNDS FROM SHARK LIVER OIL
 
Creator BAIG, MHA
BASKARAN, S
BANERJEE, S
TRIVEDI, GK
 
Description A simple and high yielding route for the stereoselective synthesis of alkyl glycerol ethers namely (2R,2'S,3Z)-1-O-(2-methoxyhexadecenyl)glycerol 1 and (2R,2'S)-1-(2'-methoxyhexadecyl) glycerol 2, isolated form Shark liver oil is reported. The key reaction involves the Wittig olefination of the chiral aldehyde 12 with the ylide generated from tridecyl triphenyl phosphonium bromide results in the formation of compound 13, a precursor for the title compounds 1 and 2.
 
Publisher PERGAMON-ELSEVIER SCIENCE LTD
 
Date 2011-08-26T15:12:47Z
2011-12-26T12:57:30Z
2011-12-27T05:42:10Z
2011-08-26T15:12:47Z
2011-12-26T12:57:30Z
2011-12-27T05:42:10Z
1995
 
Type Article
 
Identifier TETRAHEDRON, 51(16), 4723-4732
0040-4020
http://dx.doi.org/10.1016/0040-4020(95)00156-3
http://dspace.library.iitb.ac.in/xmlui/handle/10054/11351
http://hdl.handle.net/10054/11351
 
Language en