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Effects of clove oil-phospholipid mixtures on rheology of gum tragacanth - possible application for surfactant action on mucus gel simulants

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Title Effects of clove oil-phospholipid mixtures on rheology of gum tragacanth - possible application for surfactant action on mucus gel simulants
 
Creator BANERJEE, R
PUNIYANI, RR
 
Subject morphology
viscosity
eugenol
cough
surfactant
clove oil
mucus gel simulant viscosity
 
Description The present study evaluates the effectiveness of specialised biomaterials consisting of clove oil- phospholipid mixtures as possible substitute surfactants in diseases of altered mucus viscosity by studying their effect on the viscosity of mucus gel simulants in vitro. Test surfactants consisting of phospholipid-clove oil mixtures in the ratio of 1 part of oil to 9 parts of phospholipid were prepared. The phospholipids used were dipalmitoyl phosphatidylcholine (PC), phosphatidylethanolamine (PE) and phosphatidylglycerol (PG) and binary mixtures of PC: PE and PC:PG in the ratio of 2 parts of PC to 3 parts of PE or PG. The effects of the phospholipid-clove oil mixtures on the viscosity of mucus gel simulant (MGS: a polymeric gel consisting predominantly of gum tragacanth and simulating respiratory mucus), was studied by application of steady sheer rates ranging from 0.512 to 51.2/s in a concentric cylinder viscometer at 37 degreesC. The change in MGS viscosity, after incubation with surfactants, was found to have a non-Newtonian character and to follow the power law model with R-2 values >0.8. The addition of clove oil-phospholipid mixtures caused a decrease in the MCS viscosity when compared with the effect of the phospholipid alone at low shear rates in case of PC, PC and PCPG. The combination of PC: PG with clove oil caused ratios of change in MGS viscosity
 
Publisher IOS PRESS
 
Date 2011-08-04T03:36:03Z
2011-12-26T12:54:32Z
2011-12-27T05:42:31Z
2011-08-04T03:36:03Z
2011-12-26T12:54:32Z
2011-12-27T05:42:31Z
2000
 
Type Article
 
Identifier BIO-MEDICAL MATERIALS AND ENGINEERING, 10(3-4), 189-197
0959-2989
http://dspace.library.iitb.ac.in/xmlui/handle/10054/9235
http://hdl.handle.net/10054/9235
 
Language en