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IS THERE A CASE FOR HEMORHEOLOGICAL SCREENING IN THE HEMOCOMPATIBILITY TESTING OF MATERIALS

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Title IS THERE A CASE FOR HEMORHEOLOGICAL SCREENING IN THE HEMOCOMPATIBILITY TESTING OF MATERIALS
 
Creator GAUTAM, SK
KAMAT, MV
BASU, S
 
Subject hemorheology
hemocompatibility
biomaterials
iscosity
evaluation
 
Description Bio-interactions between a material and blood govern the compatibility of the material with the human body and, therefore, the single most important requirement for the blood interfacing implants/devices is haemocompatibility. The decisive events which control haemocompatibility occur at the molecular level and affect the various subphases of blood theology. This effect on the already complex human blood theology can be used to our advantage in the screening of blood-contacting materials. An attempt has been made in the present work to evaluate the haemocompatibility of materials based on changes in microrheological parameters of human blood. Samples of materials of equal surface area known to be haemocompatible (medical grade silicon, polyvinyl chloride from blood bags) and materials known to be extremely haemo-incompatible (pyrex glass, copper, cotton fabric, all commercial grade) were incubated at 37.4 degrees C in freshly drawn anticoagulated whole human blood, and changes in the haemorheological parameters (whole blood, plasma viscosity, intrinsic viscosity of red cells, platelet aggregation, albumin fibrinogen ratio) have been evaluated. The results of the study show that alterations in the haemorheological parameters are reliable indicators to the compatibility/incompatibility characteristics of well-known substances and that there is a case for haemorheological screening of biomaterials in the overall framework of haemocompatibility tests.
 
Publisher IOS PRESS
 
Date 2011-08-04T04:09:46Z
2011-12-26T12:54:32Z
2011-12-27T05:42:32Z
2011-08-04T04:09:46Z
2011-12-26T12:54:32Z
2011-12-27T05:42:32Z
1995
 
Type Article
 
Identifier BIO-MEDICAL MATERIALS AND ENGINEERING, 5(3), 141-149
0959-2989
http://dspace.library.iitb.ac.in/xmlui/handle/10054/9242
http://hdl.handle.net/10054/9242
 
Language en