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The diagnostic relevance of red cell rigidity

DSpace at IIT Bombay

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Field Value
 
Title The diagnostic relevance of red cell rigidity
 
Creator BANERJEE, R
NAGESHWARI, K
PUNIYANI, RR
 
Subject blood
deformability
filterability
hypertension
erythrocytes
membranes
lipids
 
Description Red cell rigidity is an important hemorheological parameter determining the passage of erythrocyte through narrow capillaries and the reduction of blood viscosity under high shear rates. The changes in red cell rigidity in various diseases of altered blood flow - hypertension (HT), diabetes mellitus (DM), myocardial infarction (MI) and cerebrovascular accidents (CVA), using equal sample sizes of 25 each, have been analysed in this paper. One of the essential elements of red cell rigidity is the structural and functional properties of erythrocyte membrane which, in turn, is determined by the membrane biochemistry. Since cholesterol-rich erythrocytes have increased rigidity, the serum cholesterol and triglycerides levels have been monitored in order to detect the extent to which they affect red cell rigidity. No significant change in red cell rigidity have been found in CVA. RBC rigidity is found to be significantly increased in the other diseases. Significant increase in triglyceride levels have been found in all the diseases studied. Cholesterol levels were significantly increased in all diseases except CVA. Hence, increased cholesterol levels have been found to consistently cause a simultaneous increase in RBC rigidity. Triglycerides levels, on the other hand, have not shown a consistent change with changes in RBC rigidity, but have been shown to be a more sensitive marker for early detection of diseased status.
 
Publisher IOS PRESS
 
Date 2011-08-04T04:25:13Z
2011-12-26T12:54:33Z
2011-12-27T05:42:33Z
2011-08-04T04:25:13Z
2011-12-26T12:54:33Z
2011-12-27T05:42:33Z
1998
 
Type Article
 
Identifier CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, 19(1), 21-24
1386-0291
http://dspace.library.iitb.ac.in/xmlui/handle/10054/9246
http://hdl.handle.net/10054/9246
 
Language en