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Reengineering a type II beta-turn as a potential helix nucleator-NMR characterization of Boc-Ala-Val-Pro-(D) Asp-Leu-Leu-NHMe

DSpace at IIT Bombay

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Title Reengineering a type II beta-turn as a potential helix nucleator-NMR characterization of Boc-Ala-Val-Pro-(D) Asp-Leu-Leu-NHMe
 
Creator RAJU, EB
DHANASEKARAN, M
DURANI, S
SRIVASTAVA, S
 
Subject proteins
peptide
conformation
spectra
design
model
water
type ii beta-turn
d-amino acid
peptide
nmr
helix
 
Description A stereochemically constrained type II beta-turn is reengineered over two steps into a potential helix nucleator. NMR studies in DMSO establish that the hexapeptide Boc-Alal-Val2-Pro3-(D)Asp4-Leu5-Leu6-NHMe is a type II beta-turn at Pro3-(D)Asp4 with a conformation nucleating II-bond between Asp4 carboxylate and Leu6 NH, to which is attributable a type I/III beta-turn at Leu5-Leu6-NHMe potentially capable of serving as a helix template.
 
Publisher ISTITUTI EDITORIALI E POLGRAFICI INTERNAZIONALI
 
Date 2011-08-04T07:19:25Z
2011-12-26T12:54:36Z
2011-12-27T05:42:42Z
2011-08-04T07:19:25Z
2011-12-26T12:54:36Z
2011-12-27T05:42:42Z
2000
 
Type Article
 
Identifier PHYSICA MEDICA, 16(1), 7-11
1120-1797
http://dspace.library.iitb.ac.in/xmlui/handle/10054/9281
http://hdl.handle.net/10054/9281
 
Language en