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A method for the determination of flux in elementary modes, and its application to Lactobacillus rhamnosus

DSpace at IIT Bombay

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Title A method for the determination of flux in elementary modes, and its application to Lactobacillus rhamnosus
 
Creator POOLMAN, MG
VENKATESH, KV
PIDCOCK, MK
FELL, DA
 
Subject underdetermined metabolic networks
pathways
bacteria
metabolic modeling
elementary modes
flux assignment
 
Description In this article we address the question of how, given information about the reaction fluxes of a system, flux values can be assigned to the elementary modes of that system. Having described a method by which this may be accomplished, we first illustrate its application to a hypothetical, in silico system, and then apply it to fermentation data from Lactobacillus rhamnosus. This reveals substantial changes in the flux values assigned to elementary modes, and thus to the internal metabolism, as the fermentation progresses. This is information that could not, to our knowledge, be obtained by existing methods. The relationship between our technique and the well-known method of Metabolic Flux Analysis is also discussed. (C) 2004 .
 
Publisher JOHN WILEY & SONS INC
 
Date 2011-08-04T09:44:07Z
2011-12-26T12:54:39Z
2011-12-27T05:42:49Z
2011-08-04T09:44:07Z
2011-12-26T12:54:39Z
2011-12-27T05:42:49Z
2004
 
Type Article
 
Identifier BIOTECHNOLOGY AND BIOENGINEERING, 88(5), 601-612
0006-3592
http://dx.doi.org/10.1002/bit.20273
http://dspace.library.iitb.ac.in/xmlui/handle/10054/9318
http://hdl.handle.net/10054/9318
 
Language en