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Application of the Suzuki-Miyaura cross-coupling reaction for the modification of phenylalanine peptides

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Title Application of the Suzuki-Miyaura cross-coupling reaction for the modification of phenylalanine peptides
 
Creator KOTHA, S
LAHIN, K
 
Subject amino-acid derivatives
ring-closing metathesis
diels-alder reaction
2+2+2 cycloaddition strategy
enyne metathesis
tic derivatives
solid-phase
synthetic approach
chemical synthesis
drug discovery
suzuki-miyaura coupling
post-translational peptide modifications
boronic acids
heterocycles
combinatorial chemistry
 
Description We have demonstrated an exceptionally simple and a useful methodology,for modification Of unusual phenylalanine peptides by adapting the building block approach using the Suzuki-Miyaura cross-coupling reaction as a key step. This strategy gave a good overall yield of various modified tri- and pentapeptides that may be useful to prepare various biologically active peptides in a short period of time. (C) 2003 .
 
Publisher JOHN WILEY & SONS INC
 
Date 2011-08-04T10:40:19Z
2011-12-26T12:54:41Z
2011-12-27T05:42:51Z
2011-08-04T10:40:19Z
2011-12-26T12:54:41Z
2011-12-27T05:42:51Z
2003
 
Type Article
 
Identifier BIOPOLYMERS, 69(4), 517-528
0006-3525
http://dx.doi.org/10.1002/bip.10420
http://dspace.library.iitb.ac.in/xmlui/handle/10054/9333
http://hdl.handle.net/10054/9333
 
Language en