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Systems biology of GAL regulon in Saccharomyces cerevisiae

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Title Systems biology of GAL regulon in Saccharomyces cerevisiae
 
Creator PANNALA, VR
BHAT, PJ
BHARTIYA, S
VENKATESH, KV
 
Subject transcriptional activator
genetic switch
kluyveromyces-lactis
experimental-verification
regulatory proteins
glucose repression
molecular-basis
amino-acids
dna-binding
yeast
 
Description Evolutionary success of an organism depends on its ability to express or adapt to constantly changing environmental conditions. Saccharomyces cerevisiae has evolved an elaborate genetic circuit to regulate the expression of galactose-metabolizing enzymes in the presence of galactose but in the absence of glucose. The circuit possesses molecular mechanisms such as multiple binding sites, cooperativity, autoregulation, nucleocytoplasmic shuttling, and substrate sensing mechanism. Furthermore, the GAL system consists of two positive (activating) feedback and one negative (repressing) feedback loops. These individual mechanisms, elucidated through experimental approach, can be integrated to obtain a system-wide behavior. Mathematical models in conjunction with guided experiments have demonstrated system-level properties such as ultrasensitivity, memory, noise attenuation, rapid response, and sensitive response arising out of the molecular interactions. These system-level properties allow S. cerevisiae to adapt and grow in a galactose medium under noisy and changing environments. This review focuses on system-level models and properties of the GAL regulon. (C) 2009 , Inc. WIREs Syst Biol Med 2010 2 98-106
 
Publisher JOHN WILEY & SONS INC
 
Date 2011-08-16T15:56:42Z
2011-12-26T12:55:01Z
2011-12-27T05:43:32Z
2011-08-16T15:56:42Z
2011-12-26T12:55:01Z
2011-12-27T05:43:32Z
2010
 
Type Article
 
Identifier WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE, 2(1), 98-106
1939-5094
http://dx.doi.org/10.1002/wsbm.38
http://dspace.library.iitb.ac.in/xmlui/handle/10054/9546
http://hdl.handle.net/10054/9546
 
Language en