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Structured model for batch culture growth of Lactobacillus bulgaricus

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Title Structured model for batch culture growth of Lactobacillus bulgaricus
 
Creator GADGIL, CJ
VENKATESH, KV
 
Subject cybernetic model
lactic acid
lactose
b-galactosidase
 
Description Batch fermentation kinetics of Lactobacillus bulgaricus were examined in detail using the methodology of cybernetic modelling. The effect of pH and lactate ion on the activity of the enzyme B-galactosidase was simulated. Cybernetic modelling is mainly used for simulation of growth on multiple substrates. Here, it has been incorporated in a model which simulates pH effects on single-substrate batch growth. The expression of active enymze is crucial for substrate and growth. It was seen that the effect of lactate ion on the activity of the enzyme was dependant on the system pH. A semi-empirical expression was obtained for the relative amount of active enzyme present in the organism and used to model the enzyme, biomass, substrate and lactic acid concentrations for the batch fermentation. The rate of biomass formation and product formation depended on the amount of enzyme synthesised, which in turn was dependant on the pH value of the system. The model developed simulates the effect of pH and lactate concentration on the expression and degradation of the enzyme.
 
Publisher JOHN WILEY & SONS LTD
 
Date 2011-08-17T01:04:47Z
2011-12-26T12:55:14Z
2011-12-27T05:43:58Z
2011-08-17T01:04:47Z
2011-12-26T12:55:14Z
2011-12-27T05:43:58Z
1997
 
Type Article
 
Identifier JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, 68(1), 89-93
0268-2575
http://dx.doi.org/10.1002/(SICI)1097-4660(199701)68:1<89::AID-JCTB598>3.0.CO;2-R
http://dspace.library.iitb.ac.in/xmlui/handle/10054/9688
http://hdl.handle.net/10054/9688
 
Language en