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Case-control study of non-Hodgkin's lymphoma among women and heterosexual men in the San Francisco Bay Area, California

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Title Case-control study of non-Hodgkin's lymphoma among women and heterosexual men in the San Francisco Bay Area, California
 
Creator HOLLY, EA
LELE, C
BRACCI, PM
MCGRATH, MS
 
Subject acquired-immunodeficiency-syndrome
former college-students
homosexual men
malignant-lymphomas
helicobacter-pylori
medical conditions
multiple-myeloma
gastric lymphoma
immune-system
syndrome aids
allergy and immunology
case-control studies
hypersensitivity
immunization
immunosuppression
life style
lymphoma
non-hodgkin's
risk factors
 
Description A population-based case-control study was conducted between 1988 and 1995 in the San Francisco Bay Area of California to determine risk factors for non-Hodgkin's lymphoma. Participants completed in-person interviews, and blood was drawn to test for viruses and lymphocyte subsets. This report includes data for 1,281 cases and 2,095 controls. In multivariate analyses, the factors associated with a decreased risk for non-Hodgkin's lymphoma were allergy to plants, bee and wasp stings, five or more vaccinations, drugs to lower blood cholesterol, nonsteroidal anti-inflammatory drugs, total number of sexual partners, and lifetime marijuana use, whereas an increased risk was associated with cimetidine and other histamine H-2-receptor antagonists, splenectomy, gonorrhea, and body mass index. Unique to sex-specific models was an increased risk for endocrine gland disorders among women and for polio among men. Median CD3, CD4, CD8, CD20, and lymphocyte counts for non-Hodgkin's lymphoma patients were significantly lower than those for controls. These results implicate environmental factors that may influence the early stages of lymphomagenesis by stimulating the immune system. Antigen-driven B cells that accumulate to form lymphoma may be suppressed by immunologic stresses such as exposure to an increased number of sexual partners and to certain medications. A history of allergies provides evidence for a persistent capacity for B-cell differentiation and therefore a decreased accumulation of B cells. The decreased risk for non-Hodgkin's lymphoma with use of nonsteroidal anti-inflammatory drugs and cholesterol-lowering drugs is consistent with a macrophage inflammatory role in B-cell proliferation.
 
Publisher JOHNS HOPKINS UNIV SCHOOL HYGIENE PUB HEALTH
 
Date 2011-08-17T02:48:44Z
2011-12-26T12:55:17Z
2011-12-27T05:44:03Z
2011-08-17T02:48:44Z
2011-12-26T12:55:17Z
2011-12-27T05:44:03Z
1999
 
Type Article
 
Identifier AMERICAN JOURNAL OF EPIDEMIOLOGY, 150(4), 375-389
0002-9262
http://dspace.library.iitb.ac.in/xmlui/handle/10054/9713
http://hdl.handle.net/10054/9713
 
Language en