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A new membrane probing steroidal spin label: Synthesis and applications

DSpace at IIT Bombay

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Title A new membrane probing steroidal spin label: Synthesis and applications
 
Creator KATOCH, R
TRIVEDI, GK
PHADKE, RS
 
Subject model membranes
phase-transitions
lithocholic acid
biomembranes
nitroxides
2'-(3-alpha-benzyloxy-24-norcholan-23-yl)-2',4',4'-trimethyl-4',5'-dihydrooxazo.
permeability
cholesterol
chemistry
fluidity
 
Description The applicability of a new steroidal spin label, 3-oxo-androstan-17 beta-yl-(2",2",6",6"-tetramethyl-N-oxyl) piperidyl butan-1',4'-dioate, in studying the phase transition properties of model membrane L-alpha-dipalmitoyl phosphatidyl choline (DPPC) in the presence and absence of drugs has been explored. Its synthesis and characterization has been described herein. Besides, the localization of this spin label in lipid liposomes has been studied using electron spin resonance (ESR), differential scanning calorimetry (DSC) and H-1 and P-31 NMR spectroscopic techniques. The label has also been used to study the permeability of epinephrine into membrane. The results show that the spin label has a good potential as a spin probe in the study of biomembranes.
 
Publisher NATL INST SCIENCE COMMUNICATION
 
Date 2011-08-19T03:04:31Z
2011-12-26T12:56:01Z
2011-12-27T05:44:03Z
2011-08-19T03:04:31Z
2011-12-26T12:56:01Z
2011-12-27T05:44:03Z
2000
 
Type Article
 
Identifier INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS, 37(1), 45-50
0301-1208
http://dspace.library.iitb.ac.in/xmlui/handle/10054/10204
http://hdl.handle.net/10054/10204
 
Language en