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Synthesis of highly functionalized phenylalanine derivatives via cross-enyne metathesis reactions

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Title Synthesis of highly functionalized phenylalanine derivatives via cross-enyne metathesis reactions
 
Creator KOTHA, S
HALDER, S
BRAHMACHARY, E
 
Subject amino-acid derivatives
olefin metathesis
amino acids and derivatives
metathesis
dienes
diels-alder reaction
 
Description A new method for the synthesis of constrained phenylalanine derivatives is described. In this regard, the simple synthesis of acyclic diene building blocks embodying an alpha-amino acid moiety has been achieved. The diene building blocks have been prepared by cross enyne-metathesis reaction as a key step. The Diels-Alder reaction of the dienes with a dienophile such as dimethyl acetylenedicarboxilate (DMAD) followed by oxidation of the resulting cycloadduct gave highly substituted phenylalanine derivatives. (C) 2002 . .
 
Publisher PERGAMON-ELSEVIER SCIENCE LTD
 
Date 2011-08-26T21:34:58Z
2011-12-26T12:57:36Z
2011-12-27T05:44:09Z
2011-08-26T21:34:58Z
2011-12-26T12:57:36Z
2011-12-27T05:44:09Z
2002
 
Type Article
 
Identifier TETRAHEDRON, 58(45), 9203-9208
0040-4020
http://dx.doi.org/10.1016/S0040-4020(02)01178-X
http://dspace.library.iitb.ac.in/xmlui/handle/10054/11442
http://hdl.handle.net/10054/11442
 
Language en