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Technetium-99m-cyclam AK 2123: a novel marker for tumor hypoxia

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Title Technetium-99m-cyclam AK 2123: a novel marker for tumor hypoxia
 
Creator MURUGESAN, S
SHETTY, SJ
NORONHA, OPD
SAMUEL, AM
SRIVASTAVA, TS
NAIR, CKK
KOTHARI, L
 
Subject positron emission tomography
iodoazomycin arabinoside
f-18 fluoromisonidazole
imaging agent
bms181321
tissue
tumor hypoxia
cyclam ak 2123
3-nitrotriazole
nuclear medicine imaging
row oxygen tension
 
Description Technetium-99m labeled cyclam N-2'-methoxyethyl-2-(3'-nitro-1'-triazole) acetamide (cyclam AK 2123) has been synthesized, radiolabeled and characterized as a hypoxic tumor imaging agent. Radiochemical purity was greater than 95%. Marker biodistribution was measured in normal Wistar strain rats at different time intervals after intra venous (i.v.) administration. In vivo distribution and scintigraphic imaging studies were performed after i.v. injection into mammary tumor-bearing rats using a gamma camera and associated computer. Intratumor partial oxygen pressure (pO(2)) and oxygen saturation measurements were performed to estimate the oxygenation status of the tumors. Tumor to muscle ratio (T/M) of Tc-99m-cyclam AK 2123 was 8.5 which was compared with other tumor seeking radiopharmaceuticals, viz. Tc-99m-(V) DMSA (3.07), Tc-99m-citrate (5.29) and (201)T1C1 (3.29). T/M ratios were also evaluated in comparison with radioiodinated iodoazomycin galactopyronoside (I-125-IAZG). The ratio obtained was 18 for Tc-99m-cyclam AK 2123 and 20 for I-125-IAZG, respectively. The increased concentration of radioactivity in these tumors suggests that this agent could be labelling hypoxic cells and have utility as an imaging agent. (. .
 
Publisher PERGAMON-ELSEVIER SCIENCE LTD
 
Date 2011-08-26T23:21:44Z
2011-12-26T12:57:37Z
2011-12-27T05:44:16Z
2011-08-26T23:21:44Z
2011-12-26T12:57:37Z
2011-12-27T05:44:16Z
2001
 
Type Article
 
Identifier APPLIED RADIATION AND ISOTOPES, 54(1), 81-88
0969-8043
http://dx.doi.org/10.1016/S0969-8043(00)00104-4
http://dspace.library.iitb.ac.in/xmlui/handle/10054/11463
http://hdl.handle.net/10054/11463
 
Language en