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Synthesis of conformationally constrained alpha-imino acid derivatives via ring-closing metathesis

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Title Synthesis of conformationally constrained alpha-imino acid derivatives via ring-closing metathesis
 
Creator KOTHA, S
KHEDKAR, P
 
Subject diels-alder reaction
amino-acids
olefin-metathesis
tic derivatives
azetidine-2-carboxylic acid
indolizidine alkaloids
catalysts
isomerization
heterocycles
inhibitors
peptidomemitics
conformationally constrained amino acids
conformationally constrained imino acids
ring-closing metathesis
 
Description Conformationally constrained amino acid derivatives are useful in the synthesis of peptidomimetics. Seven-, and eight-membered conformationally constrained alpha-imino acid derivatives have been prepared via RCM (ring-closing metathesis). Interestingly, attempts to achieve the synthesis of nine-membered imino acid derivative resulted in the formation of dimeric, 18-membered macrocyclic bis-alpha-imino acid derivative.
 
Publisher NATL INST SCIENCE COMMUNICATION
 
Date 2011-08-19T07:30:02Z
2011-12-26T12:56:07Z
2011-12-27T05:44:20Z
2011-08-19T07:30:02Z
2011-12-26T12:56:07Z
2011-12-27T05:44:20Z
2007
 
Type Article
 
Identifier INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 46(6), 975-979
0376-4699
http://dspace.library.iitb.ac.in/xmlui/handle/10054/10273
http://hdl.handle.net/10054/10273
 
Language en