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A dual mode of regulation of flgM by ScoC in Bacillus subtilis

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Title A dual mode of regulation of flgM by ScoC in Bacillus subtilis
 
Creator KODGIRE, P
RAO, KK
 
Subject sigma(d)-dependent gene-expression
ribosome-binding site
anti-sigma factors
translational efficiency
mutations
upstream
motility
protein
operon
hpr
bacillus subtilis
motility
scoc (hpr)
flgm
sinr
 
Description In Bacillus subtilis, the transition state regulator ScoC indirectly, negatively regulates the anti-sigma(D) factor FlgM in a SinR-dependent pathway leading to an increased availability of sigma(D). In addition to the SinR-dependent pathway, ScoC negatively regulates FlgM via directly repressing flgM transcription by binding to two sites in the promoter region of the flgM operon. Our studies also show that the regulation of FlgM by SinR is not at the transcriptional or translational levels. Thus, ScoC shows a dual mode of downregulation of FlgM, via both SinR-dependent and -independent pathways, which eventually results in the increased sigma(D) activity.
 
Publisher NATL RESEARCH COUNCIL CANADA-N R C RESEARCH PRESS
 
Date 2011-08-19T09:32:16Z
2011-12-26T12:56:10Z
2011-12-27T05:44:27Z
2011-08-19T09:32:16Z
2011-12-26T12:56:10Z
2011-12-27T05:44:27Z
2009
 
Type Article
 
Identifier CANADIAN JOURNAL OF MICROBIOLOGY, 55(8), 983-989
0008-4166
http://dx.doi.org/10.1139/W09-049
http://dspace.library.iitb.ac.in/xmlui/handle/10054/10307
http://hdl.handle.net/10054/10307
 
Language en