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1-[2-Hydroxy-3-octadecan-1'-oate]propyl-2 '',2 '',5 '',5 ''-tetramethyl pyrolidine-N-oxyl-3 ''-carboxylate as a potential spin probe for membrane structure studies

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Title 1-[2-Hydroxy-3-octadecan-1'-oate]propyl-2 '',2 '',5 '',5 ''-tetramethyl pyrolidine-N-oxyl-3 ''-carboxylate as a potential spin probe for membrane structure studies
 
Creator KATOCH, R
TRIVEDI, GK
PHADKE, RS
 
Subject model membranes
chemistry
2'-(3-alpha-benzyloxy-24-norcholan-23-yl)-2',4',4'-trimethyl-4',5'-dihydrooxazo.
nitroxides
1-[2-hydroxy-3-octadecan-1 '-oate]propyl-2 '',2 '',5 '',5 '-tetramethyl
pyrolidine-n-oxyl-3 ''-carboxylate
proxyl stearate
spin label
model membrane
phase transition
 
Description The synthesis of a new minimum steric perturbing proxyl nitroxide, which is a derivative of glycerol and contains a stearic acid moiety, has been carried out. Its localization in model membrane L-alpha-dipalmitoyl phosphatidyl choline (DPPC) was ascertained with the help of ESR, DSC, H-1 and P-31 NMR techniques. The nitroxide was used for detecting the changes in the phase transition temperature of the model membranes in the presence and absence of drugs. The permeation of the vasodilating drug epinephrine has also been studied using this spin label. The results prove the potential applicability of the new spin probe in the spin labeling of biomembranes. (C) 1999 . .
 
Publisher PERGAMON-ELSEVIER SCIENCE LTD
 
Date 2011-08-22T08:30:06Z
2011-12-26T12:56:16Z
2011-12-27T05:44:43Z
2011-08-22T08:30:06Z
2011-12-26T12:56:16Z
2011-12-27T05:44:43Z
1999
 
Type Article
 
Identifier BIOORGANIC & MEDICINAL CHEMISTRY, 7(12), 2753-2758
0968-0896
http://dx.doi.org/10.1016/S0968-0896(99)00216-3
http://dspace.library.iitb.ac.in/xmlui/handle/10054/10375
http://hdl.handle.net/10054/10375
 
Language en