Record Details

Tyrosyl phosphorylation and activation of a type II phosphatidylinositol 4-kinase by p56(lck) in concanavalin A stimulated rat splenic lymphocytes

DSpace at IIT Bombay

View Archive Info
 
 
Field Value
 
Title Tyrosyl phosphorylation and activation of a type II phosphatidylinositol 4-kinase by p56(lck) in concanavalin A stimulated rat splenic lymphocytes
 
Creator FERNANDIS, AZ
SUBRAHMANYAM, G
 
Subject cell antigen-receptor
signal-transduction
protein-kinase
purification
binding
spleen
t-cell activation
phosphorylation
signal transduction
 
Description Recent evidence suggests that concanavalin A modulates tyrosyl phosphorylation and activation of a type II PtdIns 4-kinase in rat splenic lymphocytes. However, the regulatory protein tyrosine kinase(s) remain to be elusive. The present manuscript provides evidence that a type II PtdIns 4-kinase associates with p56(lck) in Con A stimulated rat splenic lymphocytes. In vitro phosphorylation studies suggest that p561(lck) regulates phosphorylation and activation of type II PtdIns 4-kinase. Inhibition of p561(lck) activity in vivo has shown to reduce tyrosyl phosphorylation and activation of PtdIns 4-kinase by Con A. These results suggest that p56(lck) may be the physiological regulator of type II PtdIns 4-kinase. (. .
 
Publisher PERGAMON-ELSEVIER SCIENCE LTD
 
Date 2011-08-27T02:17:20Z
2011-12-26T12:57:41Z
2011-12-27T05:44:43Z
2011-08-27T02:17:20Z
2011-12-26T12:57:41Z
2011-12-27T05:44:43Z
2000
 
Type Article
 
Identifier MOLECULAR IMMUNOLOGY, 37(6), 273-280
0161-5890
http://dx.doi.org/10.1016/S0161-5890(00)00053-5
http://dspace.library.iitb.ac.in/xmlui/handle/10054/11509
http://hdl.handle.net/10054/11509
 
Language en