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A diethyltartrate-based synthesis of both (-)- and (+)-arundic acid

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Field Value
 
Title A diethyltartrate-based synthesis of both (-)- and (+)-arundic acid
 
Creator FERNANDES, RA
DHALL, A
INGLE, AB
 
Subject claisen rearrangement
therapeutic agent
enantioselective synthesis
(r)-2-propyloctanoic acid
alzheimers-disease
allylic alcohols
(r)-arundic acid
ono-2506
activation
diethyltartrate
johnson-claisen rearrangement
acute ischemic stroke therapeutic agent
arundic acid
 
Description A diethyltartrate-based synthesis of both enantiomers of the acute ischemic stroke therapeutic agent, arundic acid is presented. Separable diastereomers were obtained through the Johnson-Claisen rearrangement of the chiral vicinal diol based on the diethyltartrate skeleton and were converted separately into the two enantiomers of arundic acid. (C) 2009
 
Publisher PERGAMON-ELSEVIER SCIENCE LTD
 
Date 2011-08-23T05:33:19Z
2011-12-26T12:56:18Z
2011-12-27T05:44:47Z
2011-08-23T05:33:19Z
2011-12-26T12:56:18Z
2011-12-27T05:44:47Z
2009
 
Type Article
 
Identifier TETRAHEDRON LETTERS, 50(43), 5903-5905
0040-4039
http://dx.doi.org/10.1016/j.tetlet.2009.08.004
http://dspace.library.iitb.ac.in/xmlui/handle/10054/10407
http://hdl.handle.net/10054/10407
 
Language en