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Influence of the size of syncytial units on synaptic potentials in smooth muscle

DSpace at IIT Bombay

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Title Influence of the size of syncytial units on synaptic potentials in smooth muscle
 
Creator SOURAV, S
MANCHANDA, R
 
Subject junction potentials
vas-deferens
varicosities
smooth muscle
synaptic potentials
bidomain model
syncytium
electrophysiology
 
Description The effect of the size of syncytial bundles of cells on the passive synaptic potentials generated within them has been explored. Computer simulations have been performed of neuronally produced spontaneous excitatory junction potentials (SEJPs) generated in a cubical 'bidomain' model of syncytial tissue. It is found that indical properties of SEJPs vary conspicuously in syncytium sizes smaller than about 15-17-cube, but change very little in syncytium sizes greater than this. At the centroid of the cube, the peak amplitude V-p of the SEJP declines from 14.32 mV to 11.70 mV as syncytium size increases from 7-cube to 15-cube, i.e. a decrease of similar to 18%, while between system sires 15-cube (V-p = 11.70 mV) and 29-cube (V-p = 11.67 mV), the reduction is only similar to 0.3%. Similar trends are observed for the rime to peak of SEJPs. These observations indicate a minimum bundle size in smooth muscle below which syncytial function is modified; the implications of this are discussed.
 
Publisher PETER PEREGRINUS LTD
 
Date 2011-08-27T04:19:34Z
2011-12-26T12:57:43Z
2011-12-27T05:44:59Z
2011-08-27T04:19:34Z
2011-12-26T12:57:43Z
2011-12-27T05:44:59Z
2000
 
Type Article
 
Identifier MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, 38(3), 356-359
0140-0118
http://dx.doi.org/10.1007/BF02347058
http://dspace.library.iitb.ac.in/xmlui/handle/10054/11539
http://hdl.handle.net/10054/11539
 
Language en