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Simulation framework for electrophysiological networks: effect of syncytial properties on smooth-muscle synaptic potentials

DSpace at IIT Bombay

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Title Simulation framework for electrophysiological networks: effect of syncytial properties on smooth-muscle synaptic potentials
 
Creator TURALE, N
DEVULAPALLI, A
MANCHANDA, R
MOUDGALYA, K
SIVAKUMAR, G
 
Subject vas-deferens
current flow
varicosities
computational neuroscience
synaptic transmission
smooth muscle
syncytium
rc network
simulator
 
Description A building block-based software framework was developed to simulate electrophysiological networks. The synaptic potentials generated during neurotransmission were simulated in an existing discrete bidomain model of smooth muscle, using cubic, three-dimensional grids of varying sizes. The model is automatically derived and numerically solved, and the results of the simulation agree with previous results obtained analytically. An enhanced model was also proposed, incorporating an additional (junctional) capacitance in the network. The correctness of the model was verified, and the effect of the extra capacitance on the synaptic potentials was explored. It was found that, with a junctional capacitance C-i of 1.4 x 10(-10) F incorporated, the peak amplitude of the spontaneous excitatory junction potential V-peak declined by similar to13% at node 0 and by similar to37% at node 3x for a system size of 9(3). Similar results were obtained for different system sizes. V-peak also declined as the junctional capacitance C-i was increased. In a system of size 11(3), a 200-fold increase in C-i induced a 55% reduction at node 0. It is suggested that the type of modular simulation framework developed here may find general applicability for simulations of other physiological systems.
 
Publisher PETER PEREGRINUS LTD
 
Date 2011-08-27T04:26:35Z
2011-12-26T12:57:43Z
2011-12-27T05:44:59Z
2011-08-27T04:26:35Z
2011-12-26T12:57:43Z
2011-12-27T05:44:59Z
2003
 
Type Article
 
Identifier MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, 41(5), 589-594
0140-0118
http://dx.doi.org/10.1007/BF02345322
http://dspace.library.iitb.ac.in/xmlui/handle/10054/11540
http://hdl.handle.net/10054/11540
 
Language en