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Effects of heptanol on neurogenic contractions of vas deferens: A comparative study of stimulation frequency in guinea pig and rat

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Title Effects of heptanol on neurogenic contractions of vas deferens: A comparative study of stimulation frequency in guinea pig and rat
 
Creator PALANI, D
MANCHANDA, R
 
Subject smooth-muscle
gap-junctions
intercellular communication
field stimulation
in-vitro
transmitter release
vascular tissues
fine structure
cells
noradrenaline
rodent vas deferens
gap junction
heptanol
neurogenic contractions
smooth muscle
 
Description This study examines the role of gap junctional communication in smooth muscle in relation to the frequency of stimulation and the innervation density of the tissue in the generation of neurogenic contractions. Toward this end the effects of heptanol, a gap junctional blocker, on the neurogenic contractions of guinea pig and rat vas deferens at different frequencies of stimulation (single pulse, 5, 10, 20, 40, 60, and 80 Hz) were studied. In both the prostatic and epididymal halves of these tissues, heptanol abolished the neurogenic contractions at the lower frequencies of stimulation. At higher frequencies, contractions were resistant to heptanol action. The effect of heptanol on the neurogenic contractions was found to decrease with increasing stimulation frequency. The neurogenic contractions of rat vas deferens were more resistant to heptanol than those of guinea pig vas deferens. Our data indicate that gap junctional communication is significant in the generation of neurogenic contractions in both guinea pig and rat vas deferens in a frequency-dependent manner, and we discuss the mechanisms underlying these findings.
 
Publisher PHYSIOLOGICAL SOCIETY JAPAN
 
Date 2011-08-27T05:22:47Z
2011-12-26T12:57:44Z
2011-12-27T05:45:02Z
2011-08-27T05:22:47Z
2011-12-26T12:57:44Z
2011-12-27T05:45:02Z
2006
 
Type Article
 
Identifier JOURNAL OF PHYSIOLOGICAL SCIENCES, 56(1), 21-28
1880-6546
http://dx.doi.org/10.2170/physiolsci.RP001205
http://dspace.library.iitb.ac.in/xmlui/handle/10054/11551
http://hdl.handle.net/10054/11551
 
Language en