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A technetium-99m-labelled cyclam acid porphyrin (CAP) for tumour imaging

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Title A technetium-99m-labelled cyclam acid porphyrin (CAP) for tumour imaging
 
Creator MURUGESAN, S
SHETTY, SJ
SRIVASTAVA, TS
NORONHA, OPD
SAMUEL, AM
 
Subject photodynamic therapy
metal-complexes
radiopharmaceuticals
photosensitizers
technetium
medicine
model
tc-99m-labelled cyclam acid prophyrin
tumours
radiolabelling
imaging
 
Description A new water-soluble cyclam acid porphyrin (CAP), 5,10,15,20-tetrakis- [4-{4',8',11'-tris(carboxymethyl)-1'-(1',4',8',11'-tetraazacyclotetradecane)amidomethyleneoxy} phenyl] porphyrin has been synthesised, characterised and labelled with Tc-99m. In vivo distribution studies were performed in C-6-gliomas and N-nitroso-N-methylurea (NMU) induced mammary tumour bearing rats and scintiimages were obtained at 5 h post-administration of the labelled ligand using gamma camera computer system. Tumour to muscle (T/M) ratios were determined and compared with currently available tumour seeking radiopharmaceuticals such as Tc-99m(V)-DMSA, Tc-99m-Citrate and (TlCl)-Tl-201. In the case of NMU induced mammary tumour rats the ratios were 6.93, 1.97, 5.30 and 3.29; while in the case of C-6-gliomas the ratios were 5.58, 2.18, 3.96 and 3.02 for (99m)-Tc-CAP, (99)mTc(V)-DMSA, Tc-99m-Citrate and (TlCl)-Tl-201, respectively. (C) 2001 . .
 
Publisher PERGAMON-ELSEVIER SCIENCE LTD
 
Date 2011-08-23T10:19:55Z
2011-12-26T12:56:24Z
2011-12-27T05:45:07Z
2011-08-23T10:19:55Z
2011-12-26T12:56:24Z
2011-12-27T05:45:07Z
2001
 
Type Article
 
Identifier APPLIED RADIATION AND ISOTOPES, 55(5), 641-646
0969-8043
http://dx.doi.org/10.1016/S0969-8043(01)00113-0
http://dspace.library.iitb.ac.in/xmlui/handle/10054/10485
http://hdl.handle.net/10054/10485
 
Language en