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An efficient and stereoselective synthesis of (2R,2'S)-1-O-(2'-hydroxy-hexadecyl)glycerol and its oxo analogs: Potential antitumour compounds from shark liver oil.

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Title An efficient and stereoselective synthesis of (2R,2'S)-1-O-(2'-hydroxy-hexadecyl)glycerol and its oxo analogs: Potential antitumour compounds from shark liver oil.
 
Creator BASKARAN, S
BAIG, MHA
BANERJEE, S
BASKARAN, C
BHANU, K
DESHPANDE, SP
TRIVEDI, GK
 
Description Reproducible. high-yielding, cost efficient regio-and stereoselective synthesis of the title compound 3 isolated from Shark Liver Oil has been described. The compound 3 is prepared in an overall yield of 41% from chiral synthon 4 by the sequential reaction of 4 with C-13 Wittig salt: hydrogenation: epoxidation and regioselective opening. The oxo analogs 18 and 19 are prepared from four different achiral synthons by the sequential regioselective opening of the corresponding epoxide with different alcohols. methylation and deprotection strategies.
 
Publisher PERGAMON-ELSEVIER SCIENCE LTD
 
Date 2011-08-23T11:42:50Z
2011-12-26T12:56:26Z
2011-12-27T05:45:10Z
2011-08-23T11:42:50Z
2011-12-26T12:56:26Z
2011-12-27T05:45:10Z
1996
 
Type Article
 
Identifier TETRAHEDRON, 52(18), 6437-6452
0040-4020
http://dx.doi.org/10.1016/0040-4020(96)00278-5
http://dspace.library.iitb.ac.in/xmlui/handle/10054/10504
http://hdl.handle.net/10054/10504
 
Language en