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Synthesis and characterizations of water-based ferrofluids of substituted ferrites [Fe1−xBxFe2O4, B=Mn, Co (x=0–1)] for biomedical applications

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Title Synthesis and characterizations of water-based ferrofluids of substituted ferrites [Fe1−xBxFe2O4, B=Mn, Co (x=0–1)] for biomedical applications
 
Creator GIRI, JYOTSNENDU
PRADHAN, PALLAB
SOMANI, VAIBHAV
CHELAWAT, HITESH
CHHATRE, SHREERANG
BANERJEE, RINTI
BAHADUR, DHIRENDRA
 
Subject biomedical materials
magnetic particles
biomedical mri
hyperthermia
 
Description Nanomagnetic particles have great potential in the biomedical applications like MRI contrast enhancement, magnetic separation, targeting delivery and hyperthermia. In this paper, we have explored the possibility of biomedical applications of [Fe1−xBxFe2O4, B=Mn, Co] ferrite. Superparamagnetic particles of substituted ferrites [Fe1−xBxFe2O4, B=Mn, Co (x=0–1)] and their fatty acid coated water base ferrofluids have been successfully prepared by co-precipitation technique using NH4OH/TMAH (Tetramethylammonium hydroxide) as base. In vitro cytocompatibility study of different magnetic fluids was done using HeLa (human cervical carcinoma) cell lines. Co2+-substituted ferrite systems (e.g. CoFe2O4) is more toxic than Mn2+-substituted ferrite systems (e.g. MnFe2O4, Fe0.6Mn0.4Fe2O4). The later is as cytocompatible as Fe3O4. Thus, Fe1−xMnxFe2O4 could be useful in biomedical applications like MRI contrast agent and hyperthermia treatment of cancer.
 
Publisher Elsevier
 
Date 2009-04-23T11:41:24Z
2011-12-08T06:25:22Z
2011-12-26T13:01:33Z
2011-12-27T05:45:11Z
2009-04-23T11:41:24Z
2011-12-08T06:25:22Z
2011-12-26T13:01:33Z
2011-12-27T05:45:11Z
2008
 
Type Article
 
Identifier Journal of Magnetism and Magnetic Materials 320(5), 724-730
0304-8853
10.1016/j.jmmm.2007.08.010
http://hdl.handle.net/10054/1218
http://dspace.library.iitb.ac.in/xmlui/handle/10054/1218
 
Language en