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Antimalarial t-butylperoxyamines

DSpace at IIT Bombay

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Field Value
 
Title Antimalarial t-butylperoxyamines
 
Creator SUNDAR, N
JACOB, VT
BHAT, SV
VALECHA, N
BISWAS, S
 
Subject potential antimalarials
qinghaosu artemisinin
malaria parasites
peroxide
derivatives
chemistry
 
Description Twelve t-butylperoxyamines (6 17) were synthesized as targeted antimalarials and evaluated for antimalarial activity in vivo against Plasmodium berghei in mice and in vitro against both chloroquine sensitive and chloroquine resistant strains of Plasmodium falciparum. Compound 8 was found to have highest potency with activity at 80 and 160 mg/kg dose in vivo and compound I I exhibited highest efficacy in vitro. (C) 2001 . .
 
Publisher PERGAMON-ELSEVIER SCIENCE LTD
 
Date 2011-08-23T14:27:12Z
2011-12-26T12:56:28Z
2011-12-27T05:45:16Z
2011-08-23T14:27:12Z
2011-12-26T12:56:28Z
2011-12-27T05:45:16Z
2001
 
Type Article
 
Identifier BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 11(17), 2269-2272
0960-894X
http://dx.doi.org/10.1016/S0960-894X(01)00396-1
http://dspace.library.iitb.ac.in/xmlui/handle/10054/10545
http://hdl.handle.net/10054/10545
 
Language en