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A fluorescence study of (4-{(1E,3E)-4-[4-(dimethylamino)phenyl]buta-1,3-dienyl}phenyl)methanol and its bioconjugates with bovine and human serum albumins

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Title A fluorescence study of (4-{(1E,3E)-4-[4-(dimethylamino)phenyl]buta-1,3-dienyl}phenyl)methanol and its bioconjugates with bovine and human serum albumins
 
Creator SINGH, AK
DARSHI, M
 
Subject donor-acceptor diarylbutadienes
charge-transfer fluorescence
binding-site
probe properties
solvent
alpha,omega-diphenylpolyenes
polarity
solute
 
Description Electronic absorption and fluorescence properties of (4-{(1E,3E)-4-[4-(dimethylamino) phenyl]buta-1,3-dienyl} phenyl) methanol in different media, including organic solvents of varying polarity at 298 K, an ethanol methanol matrix at 77 K and protein environments, have been examined. The diene shows solvatochromic fluorescence, which is correlated with empirical solvent polarity parameters. The red-shifted fluorescence emission of the diene is attributed to a polar, conformationally relaxed intramolecular charge transfer excited state. Further, the diene has been covalently attached to bovine serum albumin and human serum albumin and the fluorescence probe properties of the protein-diene conjugates have been examined in phosphate buffer.
 
Publisher ROYAL SOC CHEMISTRY
 
Date 2011-08-27T12:32:47Z
2011-12-26T12:57:55Z
2011-12-27T05:46:06Z
2011-08-27T12:32:47Z
2011-12-26T12:57:55Z
2011-12-27T05:46:06Z
2004
 
Type Article
 
Identifier NEW JOURNAL OF CHEMISTRY, 28(1), 120-126
1144-0546
http://dx.doi.org/10.1039/b304951e
http://dspace.library.iitb.ac.in/xmlui/handle/10054/11663
http://hdl.handle.net/10054/11663
 
Language en