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EXPLOITING TEMPERATURE-DEPENDENCE TO IMPROVE SELECTIVITY IN MEMBRANE-BASED PLASMAPHERESIS

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Title EXPLOITING TEMPERATURE-DEPENDENCE TO IMPROVE SELECTIVITY IN MEMBRANE-BASED PLASMAPHERESIS
 
Creator GAUTAM, SK
JINDAL, S
KUDVA, C
BASU, S
 
Description Temperature effects on cross-flow membrane plasmapheresis have been investigated with the help of hydrophillic polyvinylidene fluoride (PVDF) Durapore membranes of pore size 0.65 mu m and an effective filtration area 30 cm(2), using a thin-channel device (Minitan-S, Millipore Inc., U.S.A.) and goat's blood as the working fluid. The filtration and sieving properties have been characterized by evaluating normal saline (0.9 g%) flux and the sieving coefficients of albumin, immunoglobulins, and fibrinogen respectively. Runs were performed at 10 +/- 1, 20 +/- 1, 30 +/- 1 and 40 +/- 1 degrees C, the various filtration parameters were measured and samples of the feed and permeate were collected during steady state. It is seen that the ''effective'' pore size increases with temperature increase thereby increasing flux, sieving and fouling. Exploiting temperature effects can possibly help modify the sieving spectrum in membrane-based plasmapheresis.
 
Publisher PERGAMON-ELSEVIER SCIENCE LTD
 
Date 2011-08-24T09:15:59Z
2011-12-26T12:56:50Z
2011-12-27T05:46:08Z
2011-08-24T09:15:59Z
2011-12-26T12:56:50Z
2011-12-27T05:46:08Z
1995
 
Type Article
 
Identifier TRANSFUSION SCIENCE, 16(2), 173-178
0955-3886
http://dx.doi.org/10.1016/S0955-3886(95)90038-1
http://dspace.library.iitb.ac.in/xmlui/handle/10054/10832
http://hdl.handle.net/10054/10832
 
Language en