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Chlorin p(6) as a fluorescent probe for the investigation of surfactant-cyclodextrin interactions

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Title Chlorin p(6) as a fluorescent probe for the investigation of surfactant-cyclodextrin interactions
 
Creator MISHRA, PP
ADHIKARY, R
LAHIRI, P
DATTA, A
 
Subject sodium dodecyl-sulfate
beta-cyclodextrin
aqueous-solutions
complex-formation
linear alcohols
water
p(6)
association
porphyrins
ph
 
Description Cyclodextrins (CD) are often proposed as potential vehicles in targeted drug delivery. However, if the membrane structure is disrupted by CD, then it cannot be considered to be a good drug delivery vehicle. When an extrinsic fluorescence probe is used to monitor such interactions, there are no less than three possible equilibria that can operate simultaneously: surfactant-cyclodextrin, surfactant fluorophore and cyclodextrin fluorophore. The fluorescence intensity/lifetime might be affected by all these and so, the results depend strongly on the fluorophore used as well as the nature of the surfactant. This aspect highlights the importance of the suitability of the. fluorescence probe to be used to study complicated systems and interaction. In the present work, chlorin p(6), prepared from chlorophyll from spinach leaves, has been used as the fluorescence probe to investigate the interaction between alpha-CD and beta-CD with the neutral surfactants Triton X 100 (TX 100) and cetyl trimethyl ammonium bromide (CTAB). The fluorophore is found to be a sensitive one for the study of the interaction of alpha, beta and gamma-CD with the surfactants TX 100 and CTAB. It is found that contrary to earlier reports, a complex between alpha-CD and TX 100 is formed, even though the binding constant is not very high. This observation can be obtained with chlorin p(6), which does not bind to the CDs, but not with a fluorophore, which binds to the CD as well and thus complicates the situation as the binding with CD is stronger than that between TX 100 and alpha-CD as compared to that between TNS and CD.
 
Publisher ROYAL SOC CHEMISTRY
 
Date 2011-08-28T08:17:35Z
2011-12-26T12:57:57Z
2011-12-27T05:46:29Z
2011-08-28T08:17:35Z
2011-12-26T12:57:57Z
2011-12-27T05:46:29Z
2006
 
Type Article
 
Identifier PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, 5(8), 741-747
1474-905X
http://dx.doi.org/10.1039/b601172a
http://dspace.library.iitb.ac.in/xmlui/handle/10054/11690
http://hdl.handle.net/10054/11690
 
Language en