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Effect of particle emissions from biofuel combustion on surface activity of model and therapeutic pulmonary surfactants

DSpace at IIT Bombay

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Title Effect of particle emissions from biofuel combustion on surface activity of model and therapeutic pulmonary surfactants
 
Creator KANISHTHA, T
BANERJEE, R
VENKATARAMAN, C
 
Subject air-pollution
respiratory-infections
smoke-inhalation
lung
exposure
mortality
sheep
wood
biofuel emission
pm 2.5
lung surfactant
surface tension
dppc
 
Description This study was designed to determine the effects of particle emissions from biofuel combustion in household cooking devices, commonly used in rural India, on surface activity of model lung surfactants using Langmuir monolayers. The effect of wood and dried particles from combustion of cowdung on the surface activity of model lung surfactant dipalmitoylphosphatidylcholine (DPPC), DPPC:PG (phosphatidyl glycerol) 7:3 and the therapeutic surfactant, Exosurf, were evaluated. Dried particles from combustion of cowdung in 50 wt.% mixture with DPPC elevated the gamma(min) to 15.08 +/- 1.28 mN/m and 50 wt.% particles from combustion of wood increased minimum surface tension gamma(min) to 13.46 +/- 1.70 mN/m from a zero value for DPPC alone. A graded response of inhibitory potential for all three surfactants with increasing doses was found for each type of particles. An increase in the minimum surface tension achieved by surfactants in the presence of biofuel particles implies surfactant dysfunction, a greater tendency of alveolar collapse in vivo on exposure to biofuel emissions and can lead to respiratory distress. (c) 2006
 
Publisher ELSEVIER SCIENCE BV
 
Date 2011-07-24T20:54:46Z
2011-12-26T12:48:12Z
2011-12-27T05:46:32Z
2011-07-24T20:54:46Z
2011-12-26T12:48:12Z
2011-12-27T05:46:32Z
2006
 
Type Article
 
Identifier ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 22(3), 325-333
1382-6689
http://dx.doi.org/10.1016/j.etap.2006.05.003
http://dspace.library.iitb.ac.in/xmlui/handle/10054/6537
http://hdl.handle.net/10054/6537
 
Language en