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Configurational and conformational analyses of alpha-methylene-gamma-butyro steroidal spirolactones

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Title Configurational and conformational analyses of alpha-methylene-gamma-butyro steroidal spirolactones
 
Creator SAWANT, MS
NADKARNI, PJ
DESAI, UR
KATOCH, R
KORDE, SS
TRIVEDI, GK
 
Subject sesquiterpene lactones
hydroxy
ring
 
Description The configurational and conformational analyses of alpha-methylene-gamma-butyro steroidal spirolactones have been accomplished using 2D COSY, NOESY, ROESY and HETEROCOSY in conjunction with 1D H-1 NMR. The analyses indicate that the major or the only spirolactones formed at positions 2, 3 and 6 of the steroids have the steroidal ring bearing the spirolactone in a chair conformation with an axial disposition of the oxygen atom attached to the spirocentre. The corresponding minor spirolactones have equatorial configurations. Steroids with spirolactones at positions 16 and 17 have beta and alpha dispositions, respectively, of the oxygen atom attached to the spirocentre.
 
Publisher ROYAL SOC CHEMISTRY
 
Date 2011-08-28T08:51:17Z
2011-12-26T12:57:58Z
2011-12-27T05:46:32Z
2011-08-28T08:51:17Z
2011-12-26T12:57:58Z
2011-12-27T05:46:32Z
1999
 
Type Article
 
Identifier JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, (17), 2537-2542
0300-922X
http://dx.doi.org/10.1039/a902415h
http://dspace.library.iitb.ac.in/xmlui/handle/10054/11696
http://hdl.handle.net/10054/11696
 
Language en