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SYNTHESIS, CHARACTERIZATION, AND CYTOTOXIC STUDIES OF ALPHA-DIIMINE 1,2-DIAMINE PLATINUM(II) AND PALLADIUM(II) COMPLEXES OF SELENITE AND TELLURITE AND BINDING OF SOME OF THESE COMPLEXES TO DNA

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Title SYNTHESIS, CHARACTERIZATION, AND CYTOTOXIC STUDIES OF ALPHA-DIIMINE 1,2-DIAMINE PLATINUM(II) AND PALLADIUM(II) COMPLEXES OF SELENITE AND TELLURITE AND BINDING OF SOME OF THESE COMPLEXES TO DNA
 
Creator MANSURITORSHIZI, H
MITAL, R
SRIVASTAVA, TS
PAREKH, H
CHITNIS, MP
 
Subject cis-diamminedichloroplatinum
antitumor-activity
amino-acids
ligand
cis-diamminedichloroplatinum(ii)
nephrotoxicity
generation
agents
mice
dye
 
Description Eleven new complexes of formula [M(NN)(XO3)] (where M is Pd(II) or Pt(II); NN is 2,2-bipyridine, 1,10-phenanthroline, 2,2'-dipyridylamine, ethylenediamine or (+/-)trans-1,2-diaminocyclohexane, and XO32- is SeO32- or TeO32-) have been synthesized. These water soluble complexes have been characterized by chemical analysis and conductivity measurements as well as ultraviolet-visible and infrared spectroscopy. In these complexes the selenite or tellurite ligand coordinates to platinum(II) or palladium(II) as bidentate with two oxygen atoms. These complexes inhibit the growth of P 388 lymphocytic leukemia cells, their targets are DNA. The selenite complexes invariably show I.D.50 values less than cisplatin. However, the I.D.50 values of the tellurite complexes are usually higher than cisplatin, except that of [Pd(dach)(TeO3)] which has comparable I.D.50 values, as compared to cisplatin. [Pt(bipy)(SeO3)] and [Pd(bipy)(SeO3)] have been interacted with calf thymus DNA and bind to DNA through a coordinate covalent bond.
 
Publisher ELSEVIER SCIENCE INC
 
Date 2011-07-27T12:23:34Z
2011-12-26T12:57:03Z
2011-12-27T05:46:47Z
2011-07-27T12:23:34Z
2011-12-26T12:57:03Z
2011-12-27T05:46:47Z
1991
 
Type Article
 
Identifier JOURNAL OF INORGANIC BIOCHEMISTRY, 44(4), 239-247
0162-0134
http://dx.doi.org/10.1016/0162-0134(91)84029-9
http://dspace.library.iitb.ac.in/xmlui/handle/10054/7222
http://hdl.handle.net/10054/7222
 
Language en