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Fascinating frontiers of N/O-functionalized N-heterocyclic carbene chemistry: from chemical catalysis to biomedical applications

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Title Fascinating frontiers of N/O-functionalized N-heterocyclic carbene chemistry: from chemical catalysis to biomedical applications
 
Creator JOHN, A
GHOSH, P
 
Subject ring-opening polymerization
cross-coupling reactions
phenylene ethynylene oligomers
homogeneous gold catalysis
mixed aqueous-medium
pd-peppsi-ipr
suzuki-miyaura
lactide polymerization
palladium complexes
aryl chlorides
 
Description The in vogue N-heterocyclic carbenes (NHCs) have attracted attention largely for its new found popularity in chemical catalysis and also for displaying promising traits in biomedical applications. The current perspective provides an account of our efforts in exploring the utility of N/O-functionalized N-heterocyclic carbenes in these two areas. On the catalysis front, we have employed the N/O-functionalized N-heterocyclic carbene based precatalysts for the C-C and C-N bond forming reactions like the Suzuki-Miyaura, Sonogashira and Hiyama cross-couplings, the base-free Michael addition, the alkene and alkyne hydroamination reactions and the ring-opening polymerization (ROP) of L-lactides that produce biodegradable polylactide polymers while on the biomedical application front, the anticancer and antimicrobial properties of these N/O-functionalized N-heterocyclic carbene complexes were evaluated. Towards this objective, the N-heterocyclic carbene chemistry of a variety of transition metals like Ag, Au, Ni and Pd has been investigated.
 
Publisher ROYAL SOC CHEMISTRY
 
Date 2011-08-28T11:09:01Z
2011-12-26T12:58:01Z
2011-12-27T05:46:53Z
2011-08-28T11:09:01Z
2011-12-26T12:58:01Z
2011-12-27T05:46:53Z
2010
 
Type Article
 
Identifier DALTON TRANSACTIONS, 39(31), 7183-7206
1477-9226
http://dx.doi.org/10.1039/c002475a
http://dspace.library.iitb.ac.in/xmlui/handle/10054/11726
http://hdl.handle.net/10054/11726
 
Language en