Record Details

SYNTHESIS, CHARACTERIZATION, DNA-BINDING, AND CYTOTOXIC STUDIES OF DINUCLEAR COMPLEXES OF PALLADIUM(II) AND PLATINUM(II) WITH 2,2-BIPYRIDINE AND ALPHA,OMEGA-DIAMINOALKANE-N,N'-DIACETIC ACID

DSpace at IIT Bombay

View Archive Info
 
 
Field Value
 
Title SYNTHESIS, CHARACTERIZATION, DNA-BINDING, AND CYTOTOXIC STUDIES OF DINUCLEAR COMPLEXES OF PALLADIUM(II) AND PLATINUM(II) WITH 2,2-BIPYRIDINE AND ALPHA,OMEGA-DIAMINOALKANE-N,N'-DIACETIC ACID
 
Creator JAIN, N
MITTAL, R
SRIVASTAVA, TS
SATYAMOORTHY, K
CHITNIS, MP
 
Subject mixed-ligand palladium(ii)
amino-acids
cisplatin analogs
alpha-diimine
anti-cancer
drugs
2,2'-bipyridine
agents
 
Description The synthesis of four alpha,omega-diaminoalkane-N,N'-diacetic acid and their dinuclear 2,2'-bipyridine palladium(II) and platinum(II) complexes of general formula [M(2)(bipy)(2)(DADA)] (NO3)(2) (where M is Pd(II) or Pt(II), bipy is 2,2'-bipyridine, DADA is dianion of 1,4-diaminobutane-N,N'-diacetic acid (DBDA), 1,6-diaminohexane-N,N'-diacetic acid (DHDA), 1,8-diaminooctane-N,N'-diacetic acid (DODA), or 1,10-diaminodecane-N-N'-diacetic acid (DDDA) has been achieved. They have been characterized by elemental analysis, conductivity measurements, electronic absorption, and infrared and variable temperature H-1 NMR spectroscopy. The above eight dinuclear palladium(II) and platinum(II) complexes have been tested for cytotoxicity against P388 lymphocytic leukemia cells. Out of them, [Pt-2(bipy)(2)(DDDA)](No-3)(2) and [Pd-2(bipy)(2)(DBDA)](NO3)(2) show lower I.D.(50) values as compared to cisplatin. The binding of [Pt-2(bipy)(2)(DODA)](NO3)(2) and [M(2)(bipy)(2)(DHDA)](NO3)(2) with calf thymus DNA (deoxyribonucleic acid) has also been studied. [Pt-2(bipy)(2)(DODA/DHDA)](NO3)(2) complexes show high positive cooperative binding to DNA, with Hill coefficients of 1.6 to 1.9, respectively, whereas [Pd-2(bipy)(2)(DHDA)](NO3) gives a biphasic Scatchard plot with two different binding sites or with negative cooperativity.
 
Publisher ELSEVIER SCIENCE INC
 
Date 2011-07-27T12:46:03Z
2011-12-26T12:57:07Z
2011-12-27T05:46:56Z
2011-07-27T12:46:03Z
2011-12-26T12:57:07Z
2011-12-27T05:46:56Z
1994
 
Type Article
 
Identifier JOURNAL OF INORGANIC BIOCHEMISTRY, 53(2), 79-94
0162-0134
http://dx.doi.org/10.1016/0162-0134(94)85023-2
http://dspace.library.iitb.ac.in/xmlui/handle/10054/7226
http://hdl.handle.net/10054/7226
 
Language en