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Resveratrol inhibits type II phosphatidylinositol 4-kinase: a key component in pathways of phosphoinositide turn over

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Title Resveratrol inhibits type II phosphatidylinositol 4-kinase: a key component in pathways of phosphoinositide turn over
 
Creator SRIVASTAVA, RUPA
RATHEESH, APARNA
GUDE, RAJIV K
RAO, KVK
PANDA, DULAL
SUBRAHMANYAM, GOSUKONDA
 
Subject signal transduction
infiltration
cell adhesion
enzymes
 
Description Resveratrol has anti-inflammatory, cardio protective and cancer chemopreventive properties. The molecular targets for resveratrol in early signaling cascades are not well understood. Resveratrol inhibits type II PtdIns 4-kinase but not PtdIns 3-kinase activity in vitro. Resveratrol directly binds to the enzyme with a Kd of 7.2 μM. Kinetic studies show that resveratrol competes with PtdIns binding. Inhibition of PtdIns 4-kinase activity by resveratrol/phenylarsine oxide reduces Jurkat cell adhesion to matrigel/fibronectin coated surfaces, suggesting a role for type II PtdIns 4-kinase in lymphocyte infiltration to the sites of inflammation.
 
Publisher Elsevier
 
Date 2009-04-28T05:27:47Z
2011-12-08T06:47:30Z
2011-12-26T13:01:48Z
2011-12-27T05:46:57Z
2009-04-28T05:27:47Z
2011-12-08T06:47:30Z
2011-12-26T13:01:48Z
2011-12-27T05:46:57Z
2005
 
Type Article
 
Identifier Biochemical Pharmacology 70(7), 1048-1055
http://hdl.handle.net/10054/1275
http://dspace.library.iitb.ac.in/xmlui/handle/10054/1275
 
Language en