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SYNTHESIS, CHARACTERIZATION, DNA-BINDING, AND CYTOTOXIC STUDIES OF SOME MIXED-LIGAND PALLADIUM(II) AND PLATINUM(II) COMPLEXES OF ALPHA-DIIMINE AND AMINO-ACIDS

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Title SYNTHESIS, CHARACTERIZATION, DNA-BINDING, AND CYTOTOXIC STUDIES OF SOME MIXED-LIGAND PALLADIUM(II) AND PLATINUM(II) COMPLEXES OF ALPHA-DIIMINE AND AMINO-ACIDS
 
Creator MITAL, R
SRIVASTAVA, TS
PAREKH, HK
CHITNIS, MP
 
Subject cyto-toxicity
anti-cancer
2,2'-bipyridine
agents
drugs
 
Description The syntheses of nine palladium(II) complexes of type [Pd(phen)(AA)]+ (where AA is an anion of glycine, L-alanine, L-leucine, L-phenylalanine, L-tyrosine, L-tryptophan, L-valine, L-proline, or L-serine) have been achieved. These palladium(II) complexes have been characterized by ultraviolet-visible, infrared, and H-1 NMR spectroscopy. The binding studies of several complexes [M(NN)(AA)]+ (where M is Pd(II) as Pt(II), NN is 2,2'-bipyridine or 1,10-phenanthrodine, and AA is an anion of amino acid) with calf thymus DNA have been carried out using UV difference absorption and fluorescence spectroscopy. The mode of binding of the above complexes to DNA suggests the involvement of the hydrogen bonding between them. Several complexes [M(phen)(AA)]+ (where M is Pd(II) or Pt(II) and AA is an anion of amino acid) have also been screened for cytotoxicity in P388 lymphocytic cells. Of them, only two complexes, [Pd(Phen)(Gly)]+ and [Pd(phen)(Val)]+, show comparable cytotoxicity, as cisplatin does.
 
Publisher ELSEVIER SCIENCE INC
 
Date 2011-07-27T12:51:40Z
2011-12-26T12:57:08Z
2011-12-27T05:46:58Z
2011-07-27T12:51:40Z
2011-12-26T12:57:08Z
2011-12-27T05:46:58Z
1991
 
Type Article
 
Identifier JOURNAL OF INORGANIC BIOCHEMISTRY, 41(2), 93-103
0162-0134
http://dx.doi.org/10.1016/0162-0134(91)80003-Z
http://dspace.library.iitb.ac.in/xmlui/handle/10054/7227
http://hdl.handle.net/10054/7227
 
Language en