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hag expression in Bacillus subtilis is both negatively and positively regulated by ScoC

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Title hag expression in Bacillus subtilis is both negatively and positively regulated by ScoC
 
Creator KODGIRE, P
RAO, K
 
Subject dna-binding protein
gene-expression
resistance
operon
cody
flgm
hpr
 
Description In Bacillus subtilis, motility and chemotaxis require the expression of hag, which encodes flagellin. This gene is transcribed by the sigma(D) form of RNA polymerase and is regulated by a group of proteins called transition state regulators (TSRs). Our studies show that hag transcription is negatively regulated by the transition state regulator ScoC, by binding to its promoter. Furthermore, ScoC, indirectly, also positively regulates hag by increasing the availability of sigma(D) by downregulating the levels of the anti-sigma(D)-factor FlgM. We further show that the positive regulation by ScoC predominates over the negative regulation.
 
Publisher SOC GENERAL MICROBIOLOGY
 
Date 2011-08-29T06:35:12Z
2011-12-26T12:58:27Z
2011-12-27T05:48:27Z
2011-08-29T06:35:12Z
2011-12-26T12:58:27Z
2011-12-27T05:48:27Z
2009
 
Type Article
 
Identifier MICROBIOLOGY-SGM, 155(), 142-149
1350-0872
http://dx.doi.org/10.1099/mic.0.021899-0
http://dspace.library.iitb.ac.in/xmlui/handle/10054/11998
http://hdl.handle.net/10054/11998
 
Language en