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Assessment of in vivo antimalarial activity of rifampicin, isoniazide, and ethambutol combination therapy

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Title Assessment of in vivo antimalarial activity of rifampicin, isoniazide, and ethambutol combination therapy
 
Creator ADITYA, NP
PATANKAR, S
MADHUSUDHAN, B
 
Subject biosynthesis
malaria
pathway
 
Description The existing armament of drugs for the treatment and prevention of malaria is inadequate due to development of resistance. In addition to this due to lack of economic enticement the rate of new drug development and new drug discovery in the segment of parasitic diseases is very low as compared to the other segments. This has necessitated the better deployment and usage of existing antimalarial drugs as well as discovery of antimalarial activity of drugs which are well characterized for other diseases; these approaches help to reduce the time and cost required for new drug discovery. The present study evaluated the antimalarial activity of antituberculosis drugs rifampicin, isoniazide, and ethambutol in monotherapy and combination in Plasmodium berghei-infected mice. Animals were observed for mortality, parasite progression, and toxicity for a period of 1 month. Rifampicin + isoniazide and rifampicin + isoniazide + ethambutol treatment resulted in an overall survival rate of 60% compared to 0% in vehicle-fed animals by 4 weeks after post-infection without showing any toxicity.
 
Publisher SPRINGER
 
Date 2011-08-29T09:54:41Z
2011-12-26T12:58:32Z
2011-12-27T05:48:40Z
2011-08-29T09:54:41Z
2011-12-26T12:58:32Z
2011-12-27T05:48:40Z
2010
 
Type Article
 
Identifier PARASITOLOGY RESEARCH, 106(6), 1481-1484
0932-0113
http://dx.doi.org/10.1007/s00436-010-1789-y
http://dspace.library.iitb.ac.in/xmlui/handle/10054/12047
http://hdl.handle.net/10054/12047
 
Language en