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Differences in biophysical properties of nucleus accumbens medium spiny neurons emerging from inactivation of inward rectifying potassium currents

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Title Differences in biophysical properties of nucleus accumbens medium spiny neurons emerging from inactivation of inward rectifying potassium currents
 
Creator STEEPHEN, JE
MANCHANDA, R
 
Subject hippocampal pyramidal neurons
dopaminergic modulation
projection neurons
integrative properties
dendritic calcium
ventral striatum
k+ channels
up-states
rat
shell
medium spiny neuron
inward rectifying potassium current
inactivation
 
Description Inward rectifying potassium (K(IR)) currents in medium spiny (MS) neurons of nucleus accumbens inactivate significantly in similar to 40% of the neurons but not in the rest, which may lead to differences in input processing by these two groups. Using a 189-compartment computational model of the MS neuron, we investigate the influence of this property using injected current as well as spatiotemporally distributed synaptic inputs. Our study demonstrates that K(IR) current inactivation facilitates depolarization, firing frequency and firing onset in these neurons. These effects may be attributed to the higher input resistance of the cell as well as a more depolarized resting/down-state potential induced by the inactivation of this current. In view of the reports that dendritic intracellular calcium levels depend closely on burst strength and spike onset time, our findings suggest that inactivation of K(IR) currents may offer a means of modulating both excitability and synaptic plasticity in MS neurons.
 
Publisher SPRINGER
 
Date 2011-08-29T11:45:42Z
2011-12-26T12:58:34Z
2011-12-27T05:48:45Z
2011-08-29T11:45:42Z
2011-12-26T12:58:34Z
2011-12-27T05:48:45Z
2009
 
Type Article
 
Identifier JOURNAL OF COMPUTATIONAL NEUROSCIENCE, 27(3), 453-470
0929-5313
http://dx.doi.org/10.1007/s10827-009-0161-7
http://dspace.library.iitb.ac.in/xmlui/handle/10054/12071
http://hdl.handle.net/10054/12071
 
Language en