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Effect of fluidizing agents on paclitaxel penetration in cervical cancerous monolayer membranes

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Title Effect of fluidizing agents on paclitaxel penetration in cervical cancerous monolayer membranes
 
Creator PREETHA, A
HUILGOL, N
BANERJEE, R
 
Subject molecular-interactions
controlled-release
delivery
systems
nanoparticles
surfactant
interface
liposomes
drugs
phase
paclitaxel
cervical cancer
langmuir model membrane
drug penetration
liposome
 
Description The aim of this study was to compare modulation of paclitaxel penetration in cancerous and normal cervical monolayers by four fluidizing agents: PCPG (9:1 DPPC:PG), PCPE (9:1 DPPC:DOPE), ALEC (7:3 DPPC:PG) and Exosurf (13.5:1.5:1.0 DPPC:hexadecanol:tyloxapol). Presence of the fluidizing agents improved drug penetration significantly. PCPG and PCPE were promising penetration enhancers. PCPG 0.1% caused 3.8- and 1.7-fold higher maximum increments in surface pressure due to drug penetration, ((Delta pi)(max), than the control in cancerous and normal monolayers, respectively, at 20 mN/m. In cancerous monolayer at 20 mN/m, presence of 0.1%, 0.5%, 1%, 5% and 10% PCPE produced 3.4-, 5.7-, 7.4-, 9.6- and 9.8-fold higher drug penetration compared to the control monolayer without PCPE, respectively. In cancerous monolayer at 20 mN/m, PCPG and PCPE liposomes having 1 mg lipid gave 2.1 and 3.6 times higher (Delta pi)(max) compared to the control, respectively. Further, the liposomal drug penetration was found to be directly proportional to the liposomal lipid content. The effect of the fluidizing agents was confirmed by increased calcein release from model cervical cancer liposomes. These results may have implications in using the above biocompatible lipids and surfactants as penetration enhancers along with anticancer drugs or as carriers for liposomal formulations of anticancer drugs for improved membrane penetration.
 
Publisher SPRINGER
 
Date 2011-08-29T11:54:08Z
2011-12-26T12:58:34Z
2011-12-27T05:48:46Z
2011-08-29T11:54:08Z
2011-12-26T12:58:34Z
2011-12-27T05:48:46Z
2007
 
Type Article
 
Identifier JOURNAL OF MEMBRANE BIOLOGY, 219(1-3), 83-91
0022-2631
http://dx.doi.org/10.1007/s00232-007-9064-6
http://dspace.library.iitb.ac.in/xmlui/handle/10054/12074
http://hdl.handle.net/10054/12074
 
Language en