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Ab initio structure of human seminal plasma prostatic inhibin gives significant insight into its biological functions

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Title Ab initio structure of human seminal plasma prostatic inhibin gives significant insight into its biological functions
 
Creator JOSHI, RR
JYOTHI, S
 
Subject nonparametric regression
protein structures
globular-proteins
amino-acids
beta-sheet
prediction
recognition
parameters
geometry
peptides
human seminal plasma prostatic inhibin
ab initio structure prediction
nonparametric regression
protein docking
structure-function studies
 
Description Human seminal plasma prostatic inhibin (HSPI) is a protein isolated from the human prostate gland. Despite its profound biomedical and biotechnological importance, the 3D structure of this protein of 94 amino acids remains undeciphered. The difficulties in extracting it in pure form and crystallizing it have restrained the determination of its structure experimentally. The homology- based computational methods are also not applicable, as HSPI lacks sufficient sequence homology with known structures in the protein data banks. We have predicted the structure of HSPI by a knowledge-based method using nonparametric multivariate statistical techniques. Stereochemical and other standard validation tests confirm this to be a well-refined structure. The biophysical properties exhibited by this structure are in good agreement with the NMR experimental observations. Docking and other computational studies on this structure provide significant explanation and insight into its binding activities and related biological and immunogenic functions and offer new directions for its potential applications.
 
Publisher SPRINGER-VERLAG
 
Date 2011-08-30T11:06:08Z
2011-12-26T12:58:54Z
2011-12-27T05:49:37Z
2011-08-30T11:06:08Z
2011-12-26T12:58:54Z
2011-12-27T05:49:37Z
2002
 
Type Article
 
Identifier JOURNAL OF MOLECULAR MODELING, 8(2), 50-57
0948-5023
http://dx.doi.org/10.1007/s00894-001-0063-8
http://dspace.library.iitb.ac.in/xmlui/handle/10054/12292
http://hdl.handle.net/10054/12292
 
Language en