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Effects of heptanol on electrical activity in the guinea-pig vas deferens

DSpace at IIT Bombay

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Title Effects of heptanol on electrical activity in the guinea-pig vas deferens
 
Creator MANCHANDA, R
VENKATESWARLU, K
 
Subject excitatory junction potentials
vascular smooth-muscle
intercellular communication
noradrenaline
varicosities
transmitter
atp
vasoconstriction
cotransmitters
transmission
excitatory junction potential
heptanol
vas deferens
smooth muscle
cell-to-cell communication
 
Description 1 The effects of the putative intercellular uncoupling agent 1-heptanol on electrical activity in the guinea-pig vas deferens were studied by use of intracellular and extracellular recording techniques. 2 At concentrations of 0.5, 1 and 2 mM, heptanol rapidly, monotonically and reversibly attenuated intracellularly recorded excitatory junction potential (e.j.p.) amplitude without affecting its time course, while spontaneous excitatory junction potentials (s.e.j.ps) were left unaffected. 3 Heptanol did not affect either the extracellularly recorded evoked excitatory junction current (e.j.c.), or the nerve terminal impulse that preceded it. These observations indicate that heptanol does not affect nerve impulse conduction, neurotransmitter release, or the postjunctional receptors involved in the production of the e.j.p. 4 E.j.ps appear to be suppressed by heptanol due to its intercellular uncoupling effects. Therefore, functional intercellular coupling may be necessary for the generation of the e.j.p. in smooth muscle.
 
Publisher STOCKTON PRESS
 
Date 2011-08-30T14:59:23Z
2011-12-26T12:59:01Z
2011-12-27T05:49:50Z
2011-08-30T14:59:23Z
2011-12-26T12:59:01Z
2011-12-27T05:49:50Z
1997
 
Type Article
 
Identifier BRITISH JOURNAL OF PHARMACOLOGY, 120(3), 367-370
0007-1188
http://dx.doi.org/10.1038/sj.bjp.0700900
http://dspace.library.iitb.ac.in/xmlui/handle/10054/12360
http://hdl.handle.net/10054/12360
 
Language en