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Enantioselective Synthesis of Phenyl-ethanolamines Through Application of Chiral Sulfoxide

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Field Value
 
Title Enantioselective Synthesis of Phenyl-ethanolamines Through Application of Chiral Sulfoxide
 
Creator SIVAKUMAR, AV
LAHOTI, AM
BHAT, SV
 
Subject asymmetric reduction
amino-acids
hydrogenation
cyanohydrins
derivatives
resolution
chemistry
alcohols
ketones
oxides
-amino-arylethanols
asymmetric sulfoxide
bronchodilator
chiral auxiliary
salbutamol
 
Description Efficient enantioselective synthesis of (R)- and (S)-enantiomers of 2-(tert-butylamino)-1-(p-methoxyphenyl)-ethanol has been achieved in high enantiomeric excess by using asymmetric sulfoxide as a chiral auxiliary. The present synthetic approach was further extended to the asymmetric synthesis of (R)-salbutamol.
 
Publisher TAYLOR & FRANCIS INC
 
Date 2011-08-30T17:10:03Z
2011-12-26T12:59:04Z
2011-12-27T05:49:57Z
2011-08-30T17:10:03Z
2011-12-26T12:59:04Z
2011-12-27T05:49:57Z
2009
 
Type Article
 
Identifier SYNTHETIC COMMUNICATIONS, 39(18), 3338-3347
0039-7911
http://dx.doi.org/10.1080/00397910902765578
http://dspace.library.iitb.ac.in/xmlui/handle/10054/12402
http://hdl.handle.net/10054/12402
 
Language en